Endocrine Abstracts

Background: Obesity has been associated with low levels of 25-hydroxyvitamin D (25(OH)D). This could be explained by a low dietary intake, reduced sun exposure or less biodisponibility because of its arrest in the fat mass. The main objective is to study the prevalence of 25(OH)D deficiency in premenopausal obese women.Methods: Aleatory sample of 100 morbidly obese patients. Selection criteria were: women, premenopausal, Caucasian. Patient with diabetes ...

Introduction: Obesity is a multifactorial disease in whose genetic factors are involved. The integration of this factors will allow to state personalized prevention strategies, where the constant contact with the patient will have a greater success for them to follow up recommendations. Continuous technological changes allow bigger accessibility to communication, having platforms with remote control.Objective: Assessing the effectiveness of an Intelligen...

Introduction: 46,XX testicular disorder of sex development (DSD) is a rare syndrome, which is characterized by a female karyotype in discordance with a male phenotype. It is presented with primary hypogonadism, gynecomastia and infertility. About 80–90% of 46,XX testicular DSD cases are positive for SRY gene. Appearance of external genitalia and masculinization are usually normal in 46,XX SRY-positive casesClinical case: A 41-year-old male came with...

Introduction: Sarcoidosis is a rare systemic disease where clusters of immune cells form granulomas in various organs of the body. Its prevalence ranges from 1-40 per 100,000 people in Europe. Neurological involvement of the disease occurs in 5-10% of cases, with the hypothalamus-pituitary gland being one of the most commonly affected structures.Clinical Case: A 36-year-old male with a history of hypertension, obesity, asthma and OSAS. He went to the eme...

Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, identification of novel molecular and therapeutic approaches to tackle this pathology are urgently needed. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative splicing processes might be used as potential novel therapeutic tools against PCa and castration-resistant PCa (CRPC). In this context, RBM22 ...

Prostate cancer (PCa) is one of the most common causes of cancer-related deaths in men worldwide. Therefore, more specific non-invasive diagnostic biomarkers as well as novel therapeutic targets are urgently needed. As miRNAs have been proposed as promising elements for the identification of novel diagnostic and therapeutic tools for different pathologies, including cancer, we investigated the miRNA landscape in PCa patients and explored their putative diagnostic/therapeutic u...

Prostate cancer (PCa) represents the most diagnosed tumour pathology in developed countries among men population. The main pharmacological approach to treat this pathology is based on the blockade of the androgen receptor signalling pathway, commonly known as androgen-deprivation therapy. However, some of the patients does no longer respond to this therapy, therefore developing castration-resistant prostate cancer (CRPC), the most aggressive phenotype of this pathology, which ...

Somatostatin (SST)-system is a pleiotropic hormonal system composed by several ligands/receptors that is involved in the regulation of multiple pathophysiological functions. Specifically, certain components of the SST-system are dysregulated in several endocrine-related cancer types compared to control tissues, wherein these alterations seem to influence their development/progression. However, the presence and functional role of neuronostatin (NST) and its putative G-protein c...

Introduction: Depression, anxiety and eating disorders appear more frequently in patients with type 2 diabetes and are associated with worse metabolic control and higher risk of developing micro and macrovascular complications. The aim of this study was to determine the prevalence of psychiatric comorbidities in diabetic patients, candidates for therapy with SGLT2 inhibitors (SGLT2i) and to evaluate their clinical profile and degree of metabolic control before beginning the tr...

Arterial hypertension is a major health problem affecting 1.13 billion people worldwide, of which 10% could be due to endocrine pathologies related to the mineralocorticoid receptor (MR) (i.e. primary aldosteronism, 11β-hydroxysteroid dehydrogenase type 2 enzyme (HSD11B2) deficiency). The MR pathway is expressed mainly in placenta, kidney and colon epithelial cells. Current research highlights potential epigenetic regulatory mechanisms for the MR pathway. Here, specific m...